Radionuclide Therapies

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Radionuclide Therapy

  • These are FDA-approved have been in routine clinical practice.
  • Commonly performed radionuclide therapies are:

              – Radioiodine therapies for thyroid cancer

              – Radioligand therapy for metastatic prostate cancer

              – PRRT for metastatic neuroendocrine tumors

 

  • How effective are radionuclide therapies?

Radionuclide Therapy

  • RADIOIODINE THERAPY IN THYROID CANCER
  • LUTETIUM PSMA IN METASTATIC PROSTATE CANCER
  • LUTETIUM PRRT IN METASTATIC NET
  • METASTATIC NEUROBLASTOMA
  • BONE PAIN PALLIATION

 

Success Rate

  • >90% CASES POST-SURGERY
  • 63% EVEN IN CASES RESISTANT TO CONVENTIONAL THERAPIES
  • >75% 
  • 69%
  • 80% (with single dose response lasting for upto 3 months)

RADIOIODINE THERAPY FOR THYROID CANCER

Indications

  • Remnant ablation in a post-thyroidectomy setting 
  • Treatment of metastatic thyroid cancer
  • Treatment of recurrent disease in thyroid bed on follow-up
  • Radioiodine is a colourless, tasteless water-like liquid that is administered orally
  • No major side effects of the procedure.

PEPTIDE RECEPTOR RADIONUCLIDE THERAPY

Who would benefit from PRRT ?

  • Adults with metastatic / inoperable neuroendocrine tumor

How effective is PRRT in metastatic NET ? 

  • As per published literature, PRRT  causes a 79% reduction in risk of disease progression.
  • PRRT reduces the tumour growth and achieves a stable growth-free period ranging from 1-4 years even after finishing the therapy
  • It has already been used in over 8000 patients, predominantly in the Europe
  • PRRT is an FDA approved therapy in the USA.

What are the side effects ?

  • Minor Only.

RADIOLIGAND THERAPY FOR METASTATIC PROSTATE CANCER

  • Therapy for metastatic prostate cancer has shown very promising results.
  • There are no major side effects to the treatment.

RADIONUCLIDE THERAPY FOR BONE PAIN PALLIATION

  • Beta emitting radioisotopes like Lutetium / Samarium selectively binds to these bone lesions in higher concentration and cause pain relief.
  • Single intravenous injection shows an objective response in over 80% of these patients.

Targeted CANCER Treatment with NUCLEAR Medicine Therapy

Radionuclide Therapies

  • Radionuclide therapies involve the administration of radioactive isotopes to the patient that binds to the target cells and emits radiation selectively to those specific tumor cells.
  • Therapies like Radioiodine for thyroid cancer and the more recent PRRT with Lutetium DOTATATE are FDA-approved and have been in routine clinical practice.
  • Commonly performed radionuclide therapies are:
    • Radioiodine therapies for thyroid cancer 
    • PRRT for metastatic neuroendocrine tumors 
    • Radioligand therapy for metastatic prostate cancer

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